5'-PEPTIDYL SUBSTITUENTS ALLOW A TUNING OF THE AFFINITY OF OLIGODEOXYRIBONUCLEOTIDES FOR RNA

Authors
SARRACINO DA STEINBERG JA VERGO MT WOODWORTH GF TETZLAFF CN RICHERT C
Citation
Da. Sarracino et al., 5'-PEPTIDYL SUBSTITUENTS ALLOW A TUNING OF THE AFFINITY OF OLIGODEOXYRIBONUCLEOTIDES FOR RNA, Bioorganic & medicinal chemistry letters, 8(18), 1998, pp. 2511-2516
Citations number
28
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
18
Year of publication
1998
Pages
2511 - 2516
Database
ISI
SICI code
0960-894X(1998)8:18<2511:5SAATO>2.0.ZU;2-J
Abstract
The affinity of amide-linked 5'-aminoacyl and 5'-dipeptidyl DNA octame rs for two RNA undecamers with 3'-overhangs was measured via UV meltin g analysis. A sequence-dependent increase in melting points was observ ed. At low ionic strength, two appended lysine residues elevate meltin g points more than two additional A:U base pairs. (C) 1998 Elsevier Sc ience Ltd. All rights reserved.