2 NOVEL OLEANOLIC ACID SAPONINS HAVING A SIALYL-LEWIS-X MIMETIC STRUCTURE FROM ACHYRANTHES FAURIEI ROOT

Authors
IDA Y SATOH Y KATSUMATA M NAGASAO M HIRAI Y KAJIMOTO T KATADA N YASUDA M YAMAMOTO T
Citation
Y. Ida et al., 2 NOVEL OLEANOLIC ACID SAPONINS HAVING A SIALYL-LEWIS-X MIMETIC STRUCTURE FROM ACHYRANTHES FAURIEI ROOT, Bioorganic & medicinal chemistry letters, 8(18), 1998, pp. 2555-2558
Citations number
9
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
18
Year of publication
1998
Pages
2555 - 2558
Database
ISI
SICI code
0960-894X(1998)8:18<2555:2NOASH>2.0.ZU;2-T
Abstract
Two novel triterpene glycosides, achyranthosides E and F, were isolate d as methyl eaters from the root of Achyranthes fauriei, an antiinflam matory medicinal plant. Their structures were characterized as oleanol ic acid glucuronides having unique substituents composed of C6H9O5 and C9H15O7, respectively, at the C-3 position of glucuronic acid. These compounds are active components which can inhibit the excess recruitin g of neutrophiles to injured tissues 1,000 times more potently than si alyl Lewis X. (C) 1998 Elsevier Science Ltd. All rights reserved.