SYNTHESIS AND PROPERTIES OF PRODRUGS ACTIVATED IN HYPOXIA TO GIVE BLEOMYCIN ANALOGS

Authors
HIGHFIELD JA MEHTA LK PARRICK J CANDEIAS LP WARDMAN P
Citation
Ja. Highfield et al., SYNTHESIS AND PROPERTIES OF PRODRUGS ACTIVATED IN HYPOXIA TO GIVE BLEOMYCIN ANALOGS, Bioorganic & medicinal chemistry letters, 8(18), 1998, pp. 2609-2614
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
18
Year of publication
1998
Pages
2609 - 2614
Database
ISI
SICI code
0960-894X(1998)8:18<2609:SAPOPA>2.0.ZU;2-X
Abstract
Prodrugs bioreductively activated to bleomycin analogues are reported. The production of hydroxyl radicals in the presence of Fe(II) and dio xygen by both the prodrugs and the activated products are determined a nd their in vitro cytotoxicity measured. (C) 1998 Elsevier Science Ltd . All rights reserved.