DISSOLUTION PROFILES OF FLURBIPROFEN IN PHOSPHOLIPID SOLID DISPERSIONS

This study is concerned with the development of a solid dispersion for mulation of flurbiprofen (FLP) and phospholipid (PL) with improved dis solution characteristics. The FLP powders were blended with PL to prod uce FLP-PL physical mixtures or made into solid dispersions with PL by the solvent method. The FLP exhibited significantly improved dissolut ion rates in PL coprecipitate (coppt) compared to the physical mixture s or FLP alone. The dissolution studies suggested that less than a 20: 1 ratio of FLP to PL was required to disperse FLP completely in the ca rrier. The coppt yielded a ninefold greater initial dissolution rate. Also, the total amount dissolved after 60 min was twofold greater at a IO: I ratio of FLP to L-(-dimyristoyl phosphatidylglycerol (DMPG). Si milar results were observed with a ratio as low as 20:1 (FLP:DMPG). In creasing the DMPG content did not increase the rate to any significant extent. Thus, a small PL:FLP ratio improved the dissolution to a sign ificant level. Thus, an FLP:PL dispersion may have the clinical advant ages of quick release and excellent bioavailability.