ENDOTHELIN RECEPTOR ANTAGONISTS - SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF SUBSTITUTED BENZOTHIAZINE-1,1-DIOXIDES

Authors
BERRYMAN KA EDMUNDS JJ BUNKER AM HALEEN S BRYANT J WELCH KM DOHERTY AM
Citation
Ka. Berryman et al., ENDOTHELIN RECEPTOR ANTAGONISTS - SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF SUBSTITUTED BENZOTHIAZINE-1,1-DIOXIDES, Bioorganic & medicinal chemistry, 6(9), 1998, pp. 1447-1456
Citations number
35
Categorie Soggetti
Biology,"Chemistry Medicinal","Chemistry Inorganic & Nuclear
Journal title
Bioorganic & medicinal chemistry → ACNP
ISSN journal
09680896
Volume
6
Issue
9
Year of publication
1998
Pages
1447 - 1456
Database
ISI
SICI code
0968-0896(1998)6:9<1447:ERA-SA>2.0.ZU;2-4
Abstract
The development of benzothiazine-1,1-dioxide derivatives as a new stru ctural class of potent endothelin receptor antagonists is described. S tructure-activity relationships (SAR) revealed that PD164800 (1) is a potent antagonist of the ETA receptor subtype. (C) 1998 Elsevier Scien ce Ltd. All rights reserved.