NOVEL CEPHALOSPORIN DERIVATIVES POSSESSING A BICYCLIC HETERO-CYCLE ATTHE 3-POSITION - PART II - SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF OLO[4,5-C]PYRIDINIUM-2-YL)-THIOMETHYLCEPHALOSPORIN DERIVATIVES AND RELATED-COMPOUNDS

A series of cephalosporin derivatives with a thiazolopyridinium group at the 3-position was synthesized and evaluated for antibacterial acti vity. Some of these cephalosporin derivatives having a (5-alkylthiazol o[4,5-c]pyridinium-2-yl)thiomethyl group at the 3-position showed stro ng activity against Gram-positive and Gram-negative bacteria, includin g Pseudomonas aeruginosa. Among them, 5a showed a good antibacterial s pectrum in vitro, and also showed a similar or slightly superior activ ity to that of ceftazidime in vivo against P. aeruginosa. (C) 1998 Els evier Science Ltd. All rights reserved.