Objective: To define characteristics that differentiate inner-city chi
ldren with Average or above-Average Full Scale IQ scores (greater than
or equal to 90) from those with below-Average scores (<90). Design: A
s part of a prospective study of children with and without in utero co
caine exposure tested at age 4 years on the Wechsler Preschool and Pri
mary Scales of Intelligence-Revised, we found that, taken together, on
ly 32 (21%) scored at or above 90 whereas 118 (79%) scored below 90. T
he groups (IQ greater than or equal to 90 and IQ<90) were compared on
prenatal, natal, and postnatal factors. Setting: A study center in an
inner-city hospital. Participants: One hundred-fifty children of low s
ocioeconomic status, 34 weeks' gestational age or older, and nonasphyx
iated at birth, who had intelligence testing at age 4 years; 150 careg
ivers (biological and foster). Main Outcome Measures: Association of F
ull Scale IQ with prenatal, natal, and postnatal characteristics (incl
uding caregiver-child interaction measured by the Parent Caregiver Inv
olvement Scale [PCIS], and home environment measured by the Home Obser
vation for Measurement of the Environment [HOME]). Results: The group
of children with IQs at or above 90 (n = 32) did not differ from the g
roup with IQs below 90 (n = 118) in prenatal or natal characteristics
(all P greater than or equal to.18) or proportion in foster care, atte
ndance at day care or Head Start, continued caregiver cocaine use, or
parental IQ. Children with IQs at or above 90 had more developmentally
appropriate interaction by caregivers (P = .043) and higher scores on
6 of 8 subscales and Total HOME (P less than or equal to.05) than the
group of children with IQs below 90.Conclusions: Two postnatal factor
s, home environment and caregiver-child interaction, were associated w
ith Full Scale IQ scores at or above 90 whereas prenatal and natal fac
tors were not. These potentially malleable postnatal factors can be ta
rgeted for change to improve cognitive outcome of inner-city children.