INHIBITION OF MAYARO VIRUS-REPLICATION BY PROSTAGLANDIN-A(1) AND PROSTAGLANDIN-B-2 IN VERO CELLS

The effect of prostaglandins (PGA(1), and PGB(2)) on the replication o f Mayaro virus was studied in Vero cells. PGA(1) and PGB(2) antiviral activity was found to be dose-dependent. However, while 10 mu g/ml PGB (2) inhibited virus yield by 60%, at the same dose PGA(1) suppressed v irus replication by more than 90%. SDS-PAGE analysis of [S-35]methioni ne-labelled proteins showed that PGA(1) did not alter cellular protein synthesis. In infected cells, PGA(1) slightly inhibited the synthesis of protein C, while drastically inhibiting the synthesis of glycoprot eins E-1 and E-2.