CORRELATION OF SERUM MAGNESIUM AND SERUM-LIPID LEVELS IN HEMODIALYSIS-PATIENTS

The correlation of serum magnesium and serum lipid levels was examined in 25 uremic patients on chronic hemodialysis. Patients were divided into three groups according to their total cholesterol (C) levels in p lasma. Group A: C <200 mg/dl; group B: C ranging from 201 to 250 mg/dl ; group C: C >251 mg/dl. No differences were found for HDL-C, HDL2-C, or HDL3-C. The A and B groups had similar VLDL-C levels (A: 39.1 +/- 1 5.3; B: 35.9 +/- 9.8 mg/dl), which were lower than those of group C (6 1.8 +/- 31.7 mg/dl, p<0.01). LDL-C was lower in group B (141.8 +/- 23. 1) than in group C (196.2 +/- 30.6, p<0.001), and was lowest in group A (104.3 +/- 26.5 mg/dl, p<0.001). The thr ee groups had similar Apo-A levels. Apo-B levels were highest in group C (159.5 +/- 16.9), lower in group B (128.8 +/- 12.6 p<0.001), and lowest in group A (108.0 +/- 14.5, p<0.001). Mg was higher in group B (2.1 +/- 0.2) than in group A (2.0 +/- 0.3), hut this difference was not significant. Group C had t he highest Mg levels (2.4 +/- 0.3, p<0.05). A significant linear relat ionship of total C and Mg was demonstrated (r = 0.55, p<0.001). These findings show that the increase of serum magnesium levels in hemodialy sis patients might worsen dyslipidemia.