CARBAMAZEPINE INTOXICATION WITH NEGATIVE MYOCLONUS AFTER THE ADDITIONOF CLOBAZAM

We report a case a carbamazepine (CBZ) intoxication with negative myoc lonus that occurred 4 weeks after clobazam (CLB) had been added to a s table regimen of CBZ and topiramate (TPM). Both CBZ and CBZ-epoxide (C BZ-E) blood levels were elevated, and the symptoms resolved quickly wh en CBZ dosage was reduced and CLB discontinued. CLB was reintroduced a year later with the patient's consent, and the time course of the int eraction was studied: CBZ and CBZ-E levels increased slowly over 12 da ys. The interaction is thus probably related to the progressive increa se in Nor-CLB.