PECULIARITIES OF PAXIL CLINICAL ACTION IN ENDOGENOUS DEPRESSIONS

47 patients with endogenous depressions were treated with peril (parox etine) during 4 weeks in the daily dose of 30-40 mg. Improvement of ps ychical state was observed in 89.3% of the patients; improvement was s ignificant in 78.7%. Severity of the depression reduced from 28.9 to 6 .0 scores according to Hamilton Depression Rating Scale. Antidepressiv e activity of paxil was observed at the third day of the therapy. Symp toms of depression dissappeared completely in 46.7% of the patients 2 weeks after the begining of treatment and in 62.8% of the cases in 4 w eeks. Thymoleptic and sedative-anxiolytic effects prevailed in the spe ctrum of antidepressive activity of paxil; while its stimulating effec t was expressed smaller. Mentioned peculiarities of paxil action, its small toxicity and positive subjective attitude of the patients toward s the drug make this preparation quite valuable, especially in the tre atment of classic melancholic and anxious depressions.