A 19-year-old man with a high-grade osteosarcoma of the femur, treated
with neoadjuvant chemotherapy, surgery, and adjuvant chemotherapy suf
fered from lung metastases 15 months after diagnosis. They were resect
ed. Thirteen months later, he had vague abdominal complaints which, af
ter analysis, proved to be caused by peritoneal metastasis. A review o
f the literature, possible physiopathological mechanisms of increased
occurrence of unusual metastases and the role of bone scintigraphy in
the follow-up of patients with osteosarcoma are discussed.