A NOVEL THERMAL BIOSENSOR - EVALUATION FOR DETERMINATION OF UREA IN SERUM

A novel thermal biosensor has been made based on heat conduction throu gh a BiTe-thermocouple on alumina plates. The sensing element was in c lose thermal contact with a gold tube enzyme reactor in a flow injecti on system. It was successfully applied to bovine serum samples where u rea could be determined from a calibration graph or by standard additi on. The linear range of the system was 0.5-15 mM with a detection limi t of 0.5 mM. A throughput of up to 60 samples per hour was achieved. ( C) 1998 Elsevier Science B.V. All rights reserved.