Respiratory failure plays a major role in morbidity and mortality afte
r high cervical spine injury. Initially the patients are threatened by
acute loss of motor function of the respiratory muscles and the devel
opment of neurogenic pulmonary edema. In the further course alteration
s in the mechanical properties of the respiratory system, changes in l
ung function, pulmonary infections and airway problems are the main re
asons for life threatening respiratory failure. Early surgical stabili
zation, careful weaning from mechanical ventilation, meticulous search
and treatment of infections, aggressive posturing and mobilization an
d support of impaired mechanical functions by physiotherapy, muscle tr
aining, noninvasive respiratory support and in some cases electrophren
ic pacing increase survival and independency of quadriplegic patients.