LENGTH OF INTESTINAL CONTACT ON NUTRIENT-DRIVEN SATIETY

Chemosensors throughout small bowel and colon inhibit food intakes whe n contacted by monomeric nutrients. We postulated that calorie-depende nt inhibition of food intakes depended on additions of feedbacks from sensors in proximal and distal bowel contacted after high intakes of n utrients. Therefore, we determined how feedback from sensors in proxim al gut interacted with feedback from simultaneously contacted sensors in distal bowel and whether suppression of nutrient intakes by intesti nally perfused nutrients depended on length of g-ut contacted. Suppres sion of food intakes by maltose simply added to that from dodecanoate when both were present together either in proximal or distal small bow el. When dodecanoate was infused into proximal gut while maltose was i nfused distally, suppression of intake was threefold higher and was th us potentiated. Limiting contact of slowly absorbed lactose or oleate to 35 cm of jejunum nearly abolished the satiating potencies each exhi bited during access to whole gut. The observations were consistent wit h our hypothesis.