ROLE OF SMALL-INTESTINE IN CALORIC COMPENSATIONS TO OIL PREMEALS IN RATS

We postulated that dose-responsive satiety after oil premeals varies w ith the number of gut sensors stimulated by lipolytic products along i ntestine. These experiments in fasted rats on satiety after oil premea ls were performed to 1) determine whether satiety was induced by lipol ytic products but not triglycerides; 2) confirm that oil empties from the stomach at rates that vary with oil loads; 3) ascertain that incre asing rates of oil entry into duodenum extend the length of gut contac ted by lipolytic products; and 4)judge whether length of gut contacted correlated with dose-responsive satieties to dietary oils. 5) Using s pecific antagonists, we attempted to define how satiety was signalled by gut sensors. Timing and degrees of satiety did not correlate with t iming and extent of gastric distensions but, rather, with the timing a nd extent of spread of lipolytic products along small bowel. Satiety a fter the highest premeal load of oil was blocked by Pluronic L-81, an inhibitor of intestinal secretion of apolipoprotein A-IV, but was unaf fected by MK-329 (a specific antagonist of cholecystokinin) or by caps aicin blockade of chemosensory nerves.