GASTRIC-CANCER OCCURRING IN A PATIENT WITH PLUMMER-VINSON-SYNDROME - REPORT OF A CASE

We report herein the unusual case of a 59-year-old woman with Plummer- Vinson syndrome who developed gastric cancer. The patient had a longst anding history of dysphagia and iron deficiency anemia, for which she had sporadically taken iron supplements that improved the dysphagia to some extent, but not completely. Owing to her tolerance of the dyspha gia, she had not been taking iron supplements for the past 17 years, O n admission, she was in fair nutritional condition and not anemic. Blo od chemistry results were all normal, including the serum iron level. Gastrointestinal radiographic series demonstrated cervical esophageal webs and advanced gastric cancer. Her dysphagia was successfully treat ed by endoscopic bougienage through the webs, and a distal partial gas trectomy with nodal dissection was performed. Histology of the resecte d stomach revealed atrophic mucosal change and, by chance, an adenomat ous lesion in addition to adenocarcinoma, Her postoperative course was uneventful and she is now well, without any signs of recurrence. Alth ough Plummer-Vinson syndrome is known to be associated with upper alim entary tract cancers, gastric cancer is extremely rare. A discussion o n the etiology of Plummer-Vinson syndrome and its link with potential carcinogenesis follows this case report.