THE USE OF TRICYCLIC ANTIDEPRESSANTS IN CHILDREN AND ADOLESCENTS

Tricyclic antidepressants (TCAs) have had a substantial role in the ph armacotherapy of children and adolescents over the past three decades. Recent concern about the TCA-associated adverse cardiovascular effect s in the pediatric population has resulted in decreased use of these m edications based on a limited amount of data. This article reviews the current literature regarding the clinical indications, pharmacology, and adverse effects of TCAs. Also, suggested practice guidelines based on research data and the authors' clinical experience are provided.