The evidence that gut and pancreatic endocrine cells are not derivativ
es of the neural crest is overwhelming: yet this conclusion is still n
ot universally accepted. In this editorial attention is drawn to the b
ody of experimental evidence which points conclusively to gut and panc
reatic endocrine cells arising from endoderm, nor the neural crest, th
e neurectoderm or neuroendocrine programmed epiblast. (C) 1998 John Wi
ley & Sons, Ltd.