L. Denapoli et al., A FACILE SOLID-PHASE SYNTHESIS OF OLIGONUCLEOTIDES CONTAINING A 3'-3'-PHOSPHODIESTER BOND FOR ALTERNATE STRAND TRIPLE-HELIX FORMATION, EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, (10), 1998, pp. 2119-2125
An improved protocol for the synthesis of oligonucleotides containing
a 3'-3' phosphodiester Linkage, for use in an alternate strand triple-
helix formation approach, is reported, Three 16-mers and one 24-mer ha
ve been efficiently synthesized and the corresponding triplexes have b
een analyzed by thermal denaturation experiments and CD spectroscopy.