A FACILE SOLID-PHASE SYNTHESIS OF OLIGONUCLEOTIDES CONTAINING A 3'-3'-PHOSPHODIESTER BOND FOR ALTERNATE STRAND TRIPLE-HELIX FORMATION

Authors
DENAPOLI L DIFABIO G MESSERE A MONTESARCHIO D PICCIALLI G VARRA M
Citation
L. Denapoli et al., A FACILE SOLID-PHASE SYNTHESIS OF OLIGONUCLEOTIDES CONTAINING A 3'-3'-PHOSPHODIESTER BOND FOR ALTERNATE STRAND TRIPLE-HELIX FORMATION, EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, (10), 1998, pp. 2119-2125
Citations number
19
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY → ACNP
ISSN journal
1434193X
Issue
10
Year of publication
1998
Pages
2119 - 2125
Database
ISI
SICI code
1434-193X(1998):10<2119:AFSSOO>2.0.ZU;2-7
Abstract
An improved protocol for the synthesis of oligonucleotides containing a 3'-3' phosphodiester Linkage, for use in an alternate strand triple- helix formation approach, is reported, Three 16-mers and one 24-mer ha ve been efficiently synthesized and the corresponding triplexes have b een analyzed by thermal denaturation experiments and CD spectroscopy.