NEW ALPHA-PYRONES PRODUCED BY FUNGAL CULTURE LL-11G219 FUNCTION AS ANDROGEN RECEPTOR LIGANDS

This report describes the isolation and characterization of several cl osely related compounds, produced by fungal culture LL-11G219, with an drogen-like activity. Bioassay-guided isolation yielded four novel fer mentation products of the alpha-pyrone class: 11G219 alpha, beta, gamm a, and delta. Structures were assigned to these compounds on the basis of spectroscopic data, particularly those from 1D and 2D MMR experime nts, alpha-Pyrones bearing an olefinic side chain in conjunction with a 6-alkyl substitution were hitherto unknown. (C) 1998 Elsevier Scienc e Ltd. All rights reserved.