SELECTIVE DETACHMENT OF BOC-PROTECTED AMINO-ACIDS AND PEPTIDES FROM MERRIFIELD, PAM AND WANG RESINS BY TRIMETHYLTIN HYDROXIDE

Authors
FURLAN RLE MATA EG MASCARETTI OA PENA C COBA MP
Citation
Rle. Furlan et al., SELECTIVE DETACHMENT OF BOC-PROTECTED AMINO-ACIDS AND PEPTIDES FROM MERRIFIELD, PAM AND WANG RESINS BY TRIMETHYLTIN HYDROXIDE, Tetrahedron, 54(43), 1998, pp. 13023-13034
Citations number
21
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
54
Issue
43
Year of publication
1998
Pages
13023 - 13034
Database
ISI
SICI code
0040-4020(1998)54:43<13023:SDOBAA>2.0.ZU;2-7
Abstract
We describe the development of a new non-acidolytic and non-nucleophil ic method for the selective cleavage by trimethyltin hydroxide of amin o acids and dipeptides at benzyl ester links attached to resins common ly used in peptide synthesis. (C) 1998 Elsevier Science Ltd. All right s reserved.