A NEW AND NOVEL AMIDE BOND-CLEAVAGE OF THYL-PYRROLO[2,1-C][1,4]BENZODIAZEPINE-5,11-DIONES BY HYDRIDE REDUCTION VIA 3-AZA-GROB FRAGMENTATION

Authors
WANG JJ HU WP CHUNG HW WANG LF HSU MH
Citation
Jj. Wang et al., A NEW AND NOVEL AMIDE BOND-CLEAVAGE OF THYL-PYRROLO[2,1-C][1,4]BENZODIAZEPINE-5,11-DIONES BY HYDRIDE REDUCTION VIA 3-AZA-GROB FRAGMENTATION, Tetrahedron, 54(43), 1998, pp. 13149-13154
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
54
Issue
43
Year of publication
1998
Pages
13149 - 13154
Database
ISI
SICI code
0040-4020(1998)54:43<13149:ANANAB>2.0.ZU;2-V
Abstract
A novel amide bond cleavage of N-methoxymethylpyrrolo[2, 1-c][1,4]benz odiazepine-5, 1 l-diones by hydride reduction in high yield is describ ed. MOM-protected dilactams 1 undergo ring-opening when treated with m etal hydride via 3-aza-Grob fragmentation. (C) 1998 Published by Elsev ier Science Ltd. All rights reserved.