Today, viruses and autoimmunity phenomena are at the focus of interest
in chronic hepatitis not least with respect to the differing treatmen
ts e.g. with interferon and immunosuppressants. Unfortunately, the las
t international nomenclature fails to take adequate account of the var
ious forms of chronic hepatitis of the fact that autoimmunity phenomen
a are predominantly physiological and also occur in the case of viral
hepatitides, and also that the cause of autoimmune hepatitis is not cl
ear if we wish to avoid errors we should employ a descriptive dynamic
classification and not forget that the reclassification may be needed
during the natural history of the disease. Therefore we differentiate
four groups of chronic hepatitis: group 1. viral marker and marked aut
oimmune phenomena absent. group 2. viral marker present marked autoimm
une phenomena absent. group 3. viral marker absent marked autoimmune p
henomena present. group 4. viral marker and marked autoimmune phenomen
a present.