POLYCLONAL MONOCLONAL RATIO IN KIDNEY AND BONE-MARROW TRANSPLANTED PATIENTS TREATED WITH CYCLOSPORINE/

On 296 blood samples obtained from 22 bone marrow and 21 kidney transp lanted patients, the concomitant measurements of polyclonal and monocl onal cyclosporine (CsA) were performed and the relative polyclonal/mon oclonal (P/M) ratios were calculated. Biochemical profiles of kidney a nd liver functions were also determined in all patients. For each type of transplant, biochemical data were divided into two subgroups on th e basis of P/M ratio: A) data obtained in patients with P/M ratio > 3. 0; B) data obtained in patients with P/M ratio less than or equal to 3 .0. While in kidney transplanted patients no difference of biochemical profiles was found between two subgroups, in bone marrow transplant r ecipients the subgroup A showed a worsening of hepatic function parame ters as compared to subgroup B. Therefore, it appears that P/M ratio c ould represent in bone marrow transplantation an index of hepatic CsA toxicity.