D. Capone et al., POLYCLONAL MONOCLONAL RATIO IN KIDNEY AND BONE-MARROW TRANSPLANTED PATIENTS TREATED WITH CYCLOSPORINE/, Clinical transplantation, 12(5), 1998, pp. 430-433
On 296 blood samples obtained from 22 bone marrow and 21 kidney transp
lanted patients, the concomitant measurements of polyclonal and monocl
onal cyclosporine (CsA) were performed and the relative polyclonal/mon
oclonal (P/M) ratios were calculated. Biochemical profiles of kidney a
nd liver functions were also determined in all patients. For each type
of transplant, biochemical data were divided into two subgroups on th
e basis of P/M ratio: A) data obtained in patients with P/M ratio > 3.
0; B) data obtained in patients with P/M ratio less than or equal to 3
.0. While in kidney transplanted patients no difference of biochemical
profiles was found between two subgroups, in bone marrow transplant r
ecipients the subgroup A showed a worsening of hepatic function parame
ters as compared to subgroup B. Therefore, it appears that P/M ratio c
ould represent in bone marrow transplantation an index of hepatic CsA
toxicity.