LIVER-TRANSPLANTATION IN CYSTIC-FIBROSIS - MONITORING AND FOLLOW-UP -PERSONAL-EXPERIENCE

Citation
D. Alfani et al., LIVER-TRANSPLANTATION IN CYSTIC-FIBROSIS - MONITORING AND FOLLOW-UP -PERSONAL-EXPERIENCE, Rivista italiana di pediatria, 24(2), 1998, pp. 32-33
Citations number
3
Categorie Soggetti
Pediatrics
ISSN journal
03925161
Volume
24
Issue
2
Year of publication
1998
Supplement
S
Pages
32 - 33
Database
ISI
SICI code
0392-5161(1998)24:2<32:LIC-MA>2.0.ZU;2-P
Abstract
About 5-15% of children with cystic fibrosis develop hepatic cirrhosis and progressive portal hypertension. When the portal hypertension wor sens these children are likely to develop serious variceal bleeding an d other complications including malnutrition and a decline in respirat ory function. Isolated liver transplantation is the therapy of choice in patients with cystic fibrosis affected by liver cirrhosis and initi al clinical manifestations of portal hypertension in presence of a wel l preserved pulmonary function (REV1 > 40%). Although the optimal time for liver transplantation is difficult to judge this procedure provid es a progressive improvement of patient respiratory function, nutritio nal status and quality of life, meanwhile not increasing the risk of l ung infection due to immunosuppression.