Matching production of milk components to demand improves the biologic
al efficiency and ultimately enhances the overall profitability of the
dairy industry. Consumer demand for the major components of milk has
changed considerably over the past two decades. To align production wi
th demand successfully, the dairy industry must be able to respond to
changes in consumption patterns. A better understanding of the biologi
cal control of milk protein, fat and lactose synthesis is necessary be
fore the dairy industry can fully exploit the potential to alter milk
composition. The topic of this review is the current state of knowledg
e about using dietary intervention or genetic-based techniques to alte
r the composition of bovine milk. The usefulness of the two approaches
is evaluated. The methods are also assessed in terms of both their pr
esent and anticipated abilities to exploit the biological potential to
alter the composition of milk. The scope of the article covers the de
tails of current approaches and relevant difficulties, as well as expe
cted advances that should contribute to the development of more refine
d and therefore more effective methods for selectively altering milk c
omposition. Progress in targeted modification of milk components depen
ds upon an increased understanding of lactation biology, particularly
the genetic basis of milk component synthesis. Bioactive and functiona
l components of milk are discussed in terms of target compositions for
milk and implications for human health. Advances in knowledge about r
uminant nutrition and genetics will allow the dairy industry to modify
milk composition and better match consumer demand, especially for com
ponents perceived as healthy.