GLUCOSE-CONCENTRATION IN PAROTID-SALIVA AFTER GLUCOSE FOOD INTAKE IN INDIVIDUALS WITH GLUCOSE-INTOLERANCE AND DIABETES-MELLITUS/

The concentration of glucose in parotid saliva was measured after gluc ose/food intake in two separate studies (A and B). In Study A, 10 subj ects with impaired glucose tolerance (IGT), 10 subjects with newly dia gnosed Type 2 diabetes and 12 healthy controls were included. Study B comprised 15 subjects with Type 1 or Type 2 diabetes on insulin treatm ent, nine subjects with Type 2 diabetes on treatment with oral antidia betic drugs and 12 healthy controls. After a 10-h overnight fast, the participants in Study A were given a 75 g oral glucose load, while tho se in Study B received a standardized breakfast. Citric acid-stimulate d parotid saliva was collected up to two hours after the intake. Capil lary blood and gingival exudate samples were also taken. On the basis of AUC values (area under the curve over baseline), the glucose concen tration in parotid saliva increased significantly in individuals with IGT and Type 2 diabetes compared with controls in Study A and in diabe tic patients on treatment with insulin and oral antidiabetic drugs com pared with controls in Study B. No effect by the glucose/food intake o n the glucose concentration in gingival exudate could be demonstrated in any of the studies. The correlation coefficient between the AUC val ues of glucose in saliva and blood, when all three groups were combine d, was 0.38 in Study A and 0.52 in Study B. It is concluded that the c oncentration of glucose in parotid saliva is elevated at least 2 h aft er glucose/food intake in individuals with both IGT and manifest diabe tes mellitus.