SUBEPENDYMAL GIANT-CELL ASTROCYTOMA ASSOCIATED WITH TUBEROUS SCLEROSIS - CASE-REPORT

Tuberous sclerosis is a neurocutaneous syndrome with a wide variety of clinical, pathologic, and radiologic manifestations. Intracranial pha komatosis has been reported to include subependymal nodules; cortical tubers, and subependymal giant-cell astrocytomas. Subependymal giant-c ell astrocytomas are rare, benign brain tumors of unknown histogenesis which cause increased intracranial pressure, seizures, and focal neur ologic signs. The only treatment of these tumors is total surgical rem oval, because they are not sensitive to irradiation and chemotherapy. We report a patient with tuberous sclerosis who underwent surgery for a large subependymal giant-cell astrocytoma.