A. Pujol et al., FIBER-TYPE COMPOSITION AND ENZYME-ACTIVITIES OF MUSCLES IN 2 MODELS OF OBESE RATS, Comparative biochemistry and physiology. B. Comparative biochemistry, 106(2), 1993, pp. 269-272
1. In oxidative (soleus) and glycolytic (extensor digitorum longus) mu
scles of obese Zucker rats, a significant decrease in the percentage o
f relative area occupied by glycolytic fibers was observed. 2. The act
ivity of citrate synthase and beta-hydroxy-acyl-CoA-dehydrogenase was
significantly higher in muscles of obese than of lean Zucker rats. 3.
In rats, 6 weeks after lesion of the ventromedial hypothalamus, no cha
nges were observed. 4. This indicates that neither the proportion of o
xidative fibers, nor the oxidative capacities are decreased in skeleta
l muscles of obese rats suggesting that insulin resistance cannot be a
scribed to a higher glycolytic-oxidative fiber ratio.