INSULIN-LIKE GROWTH-FACTOR BINDING-PROTEIN (IGFBP) SERUM LEVELS AND HEPATIC IGFBP-2 AND IGFBP-3 MESSENGER-RNA EXPRESSION IN DIABETIC AND INSULIN-TREATED SWINE (SUS-SCROFA)

Authors
WHITE ME LEAMAN DW RAMSAY TG KAMPMAN KA ERNST CW OSBORNE JM
Citation
Me. White et al., INSULIN-LIKE GROWTH-FACTOR BINDING-PROTEIN (IGFBP) SERUM LEVELS AND HEPATIC IGFBP-2 AND IGFBP-3 MESSENGER-RNA EXPRESSION IN DIABETIC AND INSULIN-TREATED SWINE (SUS-SCROFA), Comparative biochemistry and physiology. B. Comparative biochemistry, 106(2), 1993, pp. 341-347
Citations number
26
Categorie Soggetti
Biology
Journal title
Comparative biochemistry and physiology. B. Comparative biochemistry → ACNP
ISSN journal
03050491
Volume
106
Issue
2
Year of publication
1993
Pages
341 - 347
Database
ISI
SICI code
0305-0491(1993)106:2<341:IGB(SL>2.0.ZU;2-P
Abstract
1. Diabetes had no significant effect on IGFBP-3 message and serum lev els however, subsequent insulin treatment caused more than a two-fold increase in both hepatic IGFBP-3 mRNA and serum levels above controls (P < 0.05). 2. The induction of diabetes in pigs significantly increas ed the steady state levels of IGFBP-2 mRNA in the liver of young swine (P < 0.05). 3. Both liver message and serum IGFBP-2 were reduced to c ontrol levels with insulin therapy. 4. We report here that in addition to its affects on IGFBP-2, insulin is involved in the regulation of I GFBP-3 expression.