THE BURST PHASE IN RIBONUCLEASE-A FOLDING AND SOLVENT DEPENDENCE OF THE UNFOLDED STATE

Citation
Px. Qi et al., THE BURST PHASE IN RIBONUCLEASE-A FOLDING AND SOLVENT DEPENDENCE OF THE UNFOLDED STATE, Nature structural biology, 5(10), 1998, pp. 882-884
Citations number
28
Categorie Soggetti
Biophysics,Biology,"Cell Biology
Journal title
ISSN journal
10728368
Volume
5
Issue
10
Year of publication
1998
Pages
882 - 884
Database
ISI
SICI code
1072-8368(1998)5:10<882:TBPIRF>2.0.ZU;2-3
Abstract
Submillisecond hurst phase signals measured in kinetic protein folding experiments have been widely interpreted in terms of the fast formati on of productive folding intermediates. Experimental comparisons with non-folding polypeptide chains show that, for ribonuclease A and cytoc hrome c, these signals in fact reflect a shift from one biased ensembl e of the unfolded state to another as a function of change in denatura nt concentration.