INITIATION OF WARFARIN TREATMENT IN OUTPATIENTS WITH NONRHEUMATIC ATRIAL-FIBRILLATION - A SCHEME FOR EARLY INDICATION OF MAINTENANCE DOSE

Authors
PENGO V ZASSO A BARBERO F BIASIOLO A RAMPAZZO P BROCCO T
Citation
V. Pengo et al., INITIATION OF WARFARIN TREATMENT IN OUTPATIENTS WITH NONRHEUMATIC ATRIAL-FIBRILLATION - A SCHEME FOR EARLY INDICATION OF MAINTENANCE DOSE, Clinical and applied thrombosis/hemostasis, 4(4), 1998, pp. 274-276
Citations number
20
Categorie Soggetti
Hematology
Journal title
Clinical and applied thrombosis/hemostasis → ACNP
ISSN journal
10760296
Volume
4
Issue
4
Year of publication
1998
Pages
274 - 276
Database
ISI
SICI code
1076-0296(1998)4:4<274:IOWTIO>2.0.ZU;2-U
Abstract
Eighty-four outpatients with nonrheumatic atrial fibrillation starting oral anticoagulant treatment were administered warfarin (10 mg/day) f or the first 2 days of treatment. Prothrombin time, expressed as Inter national Normalized Ratio (INR), was measured on day 3 and plotted aga inst the weekly warfarin maintenance dose, defined as the dose able to maintain INR between 2.0 and 3.0 (therapeutic range) on three consecu tive occasions, 1 week apart. The data fit a regression line (r = 0.74 , p <.0001) that we use to estimate the weekly maintenance dose of oth er patients.