CUTANEOUS MELANOMA - PATIENT SURVEILLANCE AND TUMOR PROGRESSION

Background: The goal of surveillance examinations (SVE) in patients at high risk for cutaneous melanoma (CM) is to diagnose premetastatic tu mors. Objective: We attempted to determine whether SVE before CM diagn osis influences the histopathologic features of tumor progression. Met hods: A retrospective review was conducted of consecutive patients who presented with an intact primary CM during a 36 month period (1991 to 1994) in a university dermatology ambulatory setting. Results: Thirty -nine intact CMs were diagnosed in 34 patients, Compared with 23 CMs i n as many patients presenting at the first encounter, 16 CMs diagnosed in 11 patients during SVE had a smaller mean tumor diameter (P = .007 ) and tumor thickness (P = .002) and were more likely anatomic level I or II (P = .003) with microscopic thickness less than 0.76 mm (P = .0 1) and less than 0.50 mm (P = .002). Conclusion: Primary CMs are more likely to be smaller and thinner when diagnosed during SVE than at fir st encounter, features that are likely to have a positive impact on CM mortality.