IMMUNOHISTOCHEMICAL EXPRESSION OF SYNDECAN-1 IN HUMAN ENDOMETRIAL CANCER-CELLS

There are indications of increased frequency of endometrial cancer, on e of the most common malignancies in women. Tissue samples of normal a nd malignant endometria were obtained post operatively from 30 women. We noted expression of syndecan-1 in 40% of investigated cancers. The most differentiated cancers showed 75% of positively stained specimens , moderately differentiated 40% and poorly differentiated neoplasm did not stain at all. In normal endometrial tissue syndecan-1 expression was regular and distinct in each specimen, but immunoreactivity of the hyperplastic endometrial specimens was absent. The detection of synde can-1 in endometrial cancer of different clinical and histological sta ges could be of prognostic value in clinical diagnosis.