The pandemic impact of HIV has changed the clinical spectrum of STDs all ov
er the world. The incidence and frequency of STDs in the different global g
eographic areas demonstrate the diagnostic and treatment capabilities of va
rious local and national health systems and is simultaneously informing abo
ut the sexual behaviours of the population. The purpose of this study was t
o determine the frequency of curable STDs (herpes, chlamydia, gonorrhoea, s
yphilis, trichomoniasis) in a hospital-based STD clinic in Madrid, Spain du
ring a 4-year period. Patients were referred mainly from the emergency depa
rtment, gynecological wards, and family planning (61%) as well as from the
HIV-hospital unit (31 beds) and outpatient department (39%). The total numb
er of patients seen was 952 (243 men, 709 women) with an annual average of
238 patients per year. Of these, 139 (14.6%) were HIV-patients and 813 (85.
4%) non-HIV patients. In non-HIV patients, STDs were identified in 493 case
s (54.2%). In HIV-patients, STDs were diagnosed in 108 cases (77.7%; p less
than or equal to 0.001). Two or more STDs were more prevalent in HIV than
non-HIV patients. The frequency of STDs in both HIV and non-HIV patients we
re vulvovaginal candidiasis, 47.8%:57.2%; syphilis, 11.7%:1.4% (p less than
or equal to 0.05); gonorrhea, 5.3%:3.9%; Gardnerella vaginosis, 6.3%:4.8%;
genital chlamydia, 6.3%:9.06%; trichomoniasis, 17%:6.5% (p less than or eq
ual to 0.05); and genital herpes, 20.2%:5.3% (p less than or equal to 0.05)
.