New type of synpolydactyly of hands and feet in two unrelated males

An 18-year-old Japanese boy and a 10-year-old Chinese boy both had nearly c omplete cutaneous syndactyly of the fingers and toes, six diphalangeal fing ers on each hand, six toes on each foot (except the right foot of patient 2 ), and short, deformed, and on occasion partially fused metacarpals and met atarsals. Neither had other malformations and were of normal intelligence. The accessory toes in patient 1 were mesoaxial, each situated between the h allux and the third toe, whereas those in patient 2 were postaxial. In view of these findings, the disorder in 2 individuals is likely to represent a hitherto undescribed type of nonsyndromic synpolydactyly. Am. J, Med. Genet , 83:353-355, 1999, (C) 1999 Wiley-Liss, Inc.