Interactions between gastric volume and duodenal nutrients in the control of liquid gastric emptying

We examined the relationships between gastric volume and duodenal glucose l oad in the regulation of gastric emptying in adult male rhesus monkeys. Int ragastric glucose loads (0.125 g/ml) of volumes ranging from 150 to 375 ml empty from the stomach at the same rate from 20 to 120 min. However, to ach ieve these equivalent emptying rates, progressively larger volumes were emp tied in the initial 20 min with increasing gastric volume. Duodenal glucose infusions dose dependently inhibited the 10-min emptying of various volume s of intragastric saline. Although increasing gastric volume resulted in in creased emptying, duodenal glucose right-shifted the relationship between i nitial gastric volume and volume emptied. These data demonstrate that liqui d nutrient gastric emptying represents an interaction between gastric volum e and nutrient-induced duodenal feedback. For controlled duodenal caloric d elivery rates to be established, sufficient nutrient emptying must occur to increase the magnitude of duodenal feedback to withhold a given gastric vo lume.