The effect of tenoxicam on intraperitoneal adhesions and prostaglandin E-2levels in mice

We determined whether tenoxicam administered intraperitoneally in the preop erative period had an effect on the development of postoperative intraabdom inal adhesions (IAA). For this purpose, 100 albino mice were divided into f our random groups. Mice in Group 1 were given only 1 mt of 0.9% NaCl intrap eritoneally, whereas in Group 2, 1 mt of tenoxicam (150 mu g = 5 mg/kg) was administered. After the induction of anesthesia, a median laparotomy was p erformed, and the bowels were traumatized by touching them with powdered gl oves before the incision was closed in Groups 3 and 4. Intraperitoneal teno xicam was administered to mice in Group 4 after skin closure. All mice were killed after 14 days to determine macroscopic and microscopic IAA; prostag landin E-2 levels were also measured. Postoperative evaluation revealed a r educed IAA formation and a parallel decrease in tissue prostaglandin E-2 le vels in Group 1 and 2 mice. We conclude that intraperitoneal tenoxicam decr eased IAA formation with no peritoneal reaction in the postoperative period . Implications: Postoperative intraabdominal adhesions can cause intestinal obstruction, pelvic pain, or infertility. In this study, we showed that in traperitoneally administered tenoxicam decreases tissue prostaglandin E-2 l evels and intraabdominal adhesions in mice.