Adrenal medullary hyperplasia is often misdiagnosed. The clinical features
may resemble those of pheochromocytoma, with paroxysmal hypertension and el
evated urinary catecholamine and metanephrine levels. Pathologic study show
s diffuse or nodular adrenal medullary hyperplasia, determined by morphomet
ric analysis: increased adrenal gland weight, increased relative medullary
volume, increased relative medullary weight, decreased cortico-medullary ra
tio. Adrenal medullary hyperplasia may be primary or sporadic but is often
associated with multiple endocrine neoplasia (MEN) type II.