A primary serous papillary cystadenocarcinoma of the rectovaginal septum wa
s diagnosed in a 35-year-old woman. There were invasive microfoci in perito
neum and lymph node micrometastasis as well as a small superficial non inva
sive tumor focus in the left ovary. Diagnosis was based on morphological, i
mmunohistochemical and ultrastructural features of tumor tissue. The patien
t had surgery and post-operative chemotherapy. Progression of peritoneal di
sease was found six months after surgery. In this very rare location of ser
ous carcinoma, tumor might have developed from peritoneal inclusions in the
rectovaginal septum.