Development of resistance during antimicrobial therapy caused by insertionsequence interruption of porin genes

Authors
Hernandez-Alles, S Benedi, VJ Martinez-Martinez, L Pascual, A Aguilar, A Tomas, JM Alberti, S
Citation
S. Hernandez-alles et al., Development of resistance during antimicrobial therapy caused by insertionsequence interruption of porin genes, ANTIM AG CH, 43(4), 1999, pp. 937-939
Citations number
20
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
43
Issue
4
Year of publication
1999
Pages
937 - 939
Database
ISI
SICI code
0066-4804(199904)43:4<937:DORDAT>2.0.ZU;2-J
Abstract
We have demonstrated by using an in vitro approach that interruption of the OmpK36 porin gene by insertion sequences (ISs) is a common type of mutatio n that causes toss of porin expression and increased resistance to cefoxiti n in Klebsiella pneumoniae. This mechanism also operates in vivo: of 13 por in-deficient cefoxitin-resistant clinical isolates of K. pneumoniae, 4 pres ented ISs in their ompK36 gene.