Mutations in the gyrA, parC, and parE genes associated with fluoroquinolone resistance in clinical isolates of Mycoplasma hominis

Authors
Bebear, CM Renaudin, J Charron, A Renaudin, H de Barbeyrac, B Schaeverbeke, T Bebear, C
Citation
Cm. Bebear et al., Mutations in the gyrA, parC, and parE genes associated with fluoroquinolone resistance in clinical isolates of Mycoplasma hominis, ANTIM AG CH, 43(4), 1999, pp. 954-956
Citations number
21
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
43
Issue
4
Year of publication
1999
Pages
954 - 956
Database
ISI
SICI code
0066-4804(199904)43:4<954:MITGPA>2.0.ZU;2-J
Abstract
Five clinical isolates of Mycoplasma hominis from three different patients were examined for resistance to fluoroquinolones; some of these isolates we re probably identical. All five isolates harbored amino acid substitutions in the quinolone resistance determining regions of both DNA gyrase (GyrA) a nd topoisomerase IV (ParC or ParE), Furthermore, the novobiocin MIC for thr ee isolates showed a significant increase. This is the first characterizati on of fluoroquinolone-resistant clinical mycoplasma isolates from humans.