Growth in the presence of salicylate increases fluoroquinolone resistance in Staphylococcus aureus

Authors
Gustafson, JE Candelaria, PV Fisher, SA Goodridge, JP Lichocik, TM McWilliams, TM Price, CTD O'Brien, FG Grubb, WB
Citation
Je. Gustafson et al., Growth in the presence of salicylate increases fluoroquinolone resistance in Staphylococcus aureus, ANTIM AG CH, 43(4), 1999, pp. 990-992
Citations number
21
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
43
Issue
4
Year of publication
1999
Pages
990 - 992
Database
ISI
SICI code
0066-4804(199904)43:4<990:GITPOS>2.0.ZU;2-B
Abstract
Salicylate and acetylsalicylate slightly increased fluoroquinolone resistan ce in ciprofloxacin-susceptible and -resistant Staphylococcus aureus. Salic ylate allowed a greater number of cells from ciprofloxacin-susceptible and -resistant strains to survive on high fluoroquinolone concentrations. Salic ylate also increased the frequency with which a susceptible strain mutated to become more resistant to ciprofloxacin.