Potentiation of isoniazid activity against Mycobacterium tuberculosis by melatonin

Authors
Wiid, I Hoal-van Helden, E Hon, D Lombard, C van Helden, P
Citation
I. Wiid et al., Potentiation of isoniazid activity against Mycobacterium tuberculosis by melatonin, ANTIM AG CH, 43(4), 1999, pp. 975-977
Citations number
19
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
43
Issue
4
Year of publication
1999
Pages
975 - 977
Database
ISI
SICI code
0066-4804(199904)43:4<975:POIAAM>2.0.ZU;2-#
Abstract
The limited number of effective antituberculosis drugs available necessitat es optimizing current treatments. We show that melatonin, which is synthesi zed in the pineal gland, can cause at least a threefold increase in the eff icacy of isoniazid. This suggests that tuberculosis chemotherapy can be imp roved by innate molecules such as melatonin.