Mg. Ramos et al., Protection by short-chain fatty acids against 1-beta-D-arabinofuranosylcytosine-induced intestinal lesions in germfree mice, ANTIM AG CH, 43(4), 1999, pp. 950-953
In germfree mice, the administration of short-chain fatty acids (SCFA) prot
ected the intestinal mucosa from damage produced by 1-beta-D-arabinofuranos
ylcytosine (Ara-C). Animals receiving SCFA and Ara-C had intestinal morphol
ogies closer to normal than the control animals, which had severe intestina
l lesions. We concluded that orally administrated SCFA reduce intestinal le
sions, improving the mucosa pattern of the small intestine and colon.