Protection by short-chain fatty acids against 1-beta-D-arabinofuranosylcytosine-induced intestinal lesions in germfree mice

Authors
Ramos, MG Bambirra, EA Nicoli, JR Cara, DC Vieira, EC Alvarez-Leite, J
Citation
Mg. Ramos et al., Protection by short-chain fatty acids against 1-beta-D-arabinofuranosylcytosine-induced intestinal lesions in germfree mice, ANTIM AG CH, 43(4), 1999, pp. 950-953
Citations number
14
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
43
Issue
4
Year of publication
1999
Pages
950 - 953
Database
ISI
SICI code
0066-4804(199904)43:4<950:PBSFAA>2.0.ZU;2-N
Abstract
In germfree mice, the administration of short-chain fatty acids (SCFA) prot ected the intestinal mucosa from damage produced by 1-beta-D-arabinofuranos ylcytosine (Ara-C). Animals receiving SCFA and Ara-C had intestinal morphol ogies closer to normal than the control animals, which had severe intestina l lesions. We concluded that orally administrated SCFA reduce intestinal le sions, improving the mucosa pattern of the small intestine and colon.