Trovafloxacin in combination with vancomycin against penicillin-resistant pneumococci in the rabbit meningitis model

Authors
Rodoni, D Hanni, F Gerber, CM Cottagnoud, M Neftel, K Tauber, MG Cottagnoud, P
Citation
D. Rodoni et al., Trovafloxacin in combination with vancomycin against penicillin-resistant pneumococci in the rabbit meningitis model, ANTIM AG CH, 43(4), 1999, pp. 963-965
Citations number
18
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
43
Issue
4
Year of publication
1999
Pages
963 - 965
Database
ISI
SICI code
0066-4804(199904)43:4<963:TICWVA>2.0.ZU;2-A
Abstract
Trovafloxacin, a neu fluoroquinolone, produced bactericidal activity (-0.33 +/- 0.13 Delta log(10) CFU/ml . h; intravenously [i.v.] administered dose, 15 mg/kg) comparable to that of vancomycin (-0.39 +/- 0.18 Delta log(10) C FU/ml . h; i.v, administered dose, 20 mg/kg) in the treatment of experiment al meningitis in rabbits due to a pneumococcal strain highly resistant to p enicillin (MIC of penicillin G, 4 mu g/ml). The combination of both drugs s ignificantly increased (P < 0.05) the killing rate (-0.60 +/- 0.23 Delta lo g(10) CFU/ml . h) compared to that produced by either monotherapy, These re sults were also confirmed in vitro.