D. Rodoni et al., Trovafloxacin in combination with vancomycin against penicillin-resistant pneumococci in the rabbit meningitis model, ANTIM AG CH, 43(4), 1999, pp. 963-965
Trovafloxacin, a neu fluoroquinolone, produced bactericidal activity (-0.33
+/- 0.13 Delta log(10) CFU/ml . h; intravenously [i.v.] administered dose,
15 mg/kg) comparable to that of vancomycin (-0.39 +/- 0.18 Delta log(10) C
FU/ml . h; i.v, administered dose, 20 mg/kg) in the treatment of experiment
al meningitis in rabbits due to a pneumococcal strain highly resistant to p
enicillin (MIC of penicillin G, 4 mu g/ml). The combination of both drugs s
ignificantly increased (P < 0.05) the killing rate (-0.60 +/- 0.23 Delta lo
g(10) CFU/ml . h) compared to that produced by either monotherapy, These re
sults were also confirmed in vitro.