Pharmacokinetics of oral zidovudine entrapped in biodegradable nanospheresin rabbits

Authors
Callender, DP Jayaprakash, N Bell, A Petraitis, V Petratienes, R Candelario, M Schaufele, R Dunn, JM Sei, S Walsh, TJ Balis, FM
Citation
Dp. Callender et al., Pharmacokinetics of oral zidovudine entrapped in biodegradable nanospheresin rabbits, ANTIM AG CH, 43(4), 1999, pp. 972-974
Citations number
13
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
43
Issue
4
Year of publication
1999
Pages
972 - 974
Database
ISI
SICI code
0066-4804(199904)43:4<972:POOZEI>2.0.ZU;2-3
Abstract
The pharmacokinetic profile of oral zidovudine entrapped in a 50:50 polyact ide-coglycolide matrix (nanospheres) was compared to those of standard oral and parenteral zidovudine formulations in rabbits. The bioavailability of zidovudine nanospheres at 50 mg/kg of body weight was 76%, and this dose ac hieved prolonged exposure to zidovudine compared to standard formulations w ithout an increase in the drug's peak concentration.