Synthesis and antileishmanial activity of alpha-cyano ethyl propenoates - A new class of antileishmanials

Authors
Tiwari, S Gupta, S Tripathi, RP Khan, AR Katiyar, JC Bhaduri, AP
Citation
S. Tiwari et al., Synthesis and antileishmanial activity of alpha-cyano ethyl propenoates - A new class of antileishmanials, ARZNEI-FOR, 49(2), 1999, pp. 144-148
Citations number
16
Categorie Soggetti
Pharmacology & Toxicology
Journal title
ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH
ISSN journal
00044172 → ACNP
Volume
49
Issue
2
Year of publication
1999
Pages
144 - 148
Database
ISI
SICI code
0004-4172(199902)49:2<144:SAAAOA>2.0.ZU;2-E
Abstract
A number of alpha-cyano-beta-substituted ethyl propenoates were synthesised by condensation of appropriate aldehydes with ethyl cyanoacetate in basic medium. These compounds have been studied for their antileishmanial activit ies in vivo in hamsters. Two compounds exhibited 70-77 % activities both by intramuscular and oral routes.