L. Novotny et al., Polarographic properties and potential carcinogenicity of some natural nucleosides and their synthetic analogues, BIOELECTR B, 48(1), 1999, pp. 129-134
The polarographic reduction and the index of potential carcinogenicity tg c
t determined polarographically in aprotic conditions and in the presence of
ol-lipoic acid of nine naturally occurring and synthetic pyrimidine and si
x synthetic 1,3,5-triazine (5-aza) nucleosides was compared to the reductio
n of eight synthetic 1,3,6-triazine (6-aza) nucleosides. Nucleosides are of
interest because of their key role in the nucleic acid structure and becau
se of the antimetabolite and cytotoxic/antileukemia properties of their syn
thetic analogues. It was shown that polarographic reduction of the studied
compounds is achieved at gradually increased potentials in the order of 6-a
za < 5-aza < pyrimidine nucleosides. On other hand, the potential carcinoge
nicity of studied compounds increases usually in the order of pyrimidine <
6-aza <<5-aza nucleoside. The only compounds with remarkable potential carc
inogenicity identified at this study were those ones from the 5-aza (1,3,5-
triazine) antimetabolite series - arabinosyl-5-azacytosine (0.275), 5-aza-c
ytidine (0.295) and 5-aza-uracil (0.400) - and 2,2'-anhydrouridine (0.260).
The relation of the data obtained to biological activity of nucleosides in
cluded in the study is discussed. (C) 1999 Elsevier Science S.A. All rights
reserved.